Chiral separations of phyretroic acids using cyclodextrin selectros

Abstract

The pyrethroid insecticides are broadly used insecticides. They are used also near food insecticides in households because they have low toxicity for warm blooded living creatures. On the other hand, they show high toxicity not only for insecticides but for fishes too. Therefore, it is important to decrease the environmental burden of the pyrethroids. One of the effective ways to decrease the pollution using chiral pure insecticide products instead of their racemic mixtures. For example, the chiral pure deltamethrin has same insecticide effect than the eight times more amount racemic mixture of deltamethrin. The enantiomer pure products require enantiomer selective synthesis and analysis. The pyrethroic acids are chiral compounds. Their chiral selective syntheses are necessary therefore their chiral selective analyses are crucial. The chiral selective analyses of pyrethroic acids are also important from the point of view of their degradation metabolism in the environment. This study shows various enantiomeric selective chromatographic methods: gas chromatography, supercritical fluid chromatography and capillary electrophoresis for separation of various pyrethroic acids. The used chiral selective agents were based on cyclodextrin derivatives. To find the appropriate chiral selective selector is the result of a trial-and-error method development. This systematic study explores the correlation of chiral selectivity-analyte structure using different pyrethroic acids in various derivatives forms.