Study the effect of vitamin D3 in type 2 diabetic Iraqi patients with chronic kidney diseases

Abstract

Low vitamin D levels are associated with mortality in hemodialysis (HD) patients; however, the serum vitamin D thresholds are unclear. This study aimed to identify the vitamin D level below which mortality increases in HD patients. This study was designed to evaluate the vitamin D3 levels in Iraqi patients with chronic kidney disease and type 2 diabetes for both genders. Sixty Iraqi patients with chronic kidney disease and type 2 diabetes depended the hemodialysis duration less than 1 year; their age ranged between (33-60) years and compared with 30 healthy subjects as control group; their age ranged between (30-55) years, who were attending Al-Yarmok Teaching Hospital through September 2019 to March 2020. Anthropometric and biochemical parameters were measured for patients and controls. The baseline characteristics of study population are shown in Table 1. There were significant increases (p < 0.05) in glycemic test, urea, total cholesterol, triacylglycerol, low density lipoprotein cholesterol. While, there were significant decreases (p < 0.05) in high density lipoprotein cholesterol, glomerular filtration rate, and vitamin D3 in patients group as compared to the controls. Moreover, there were elevations in age and body mass index in patients group as compared to the controls. There were significant increases (p < 0.05) in fasting serum glucose, serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol. While, there were significant decreases in high density lipoprotein cholesterol, glomerular filtration rate, and vitamin D3 in female patients as compared to the males. Moreover, there were elevations in body mass index, urea, and creatinine in female patients as compared to the males. Hypovitaminosis D was seen in Chronic Kidney disease (CKD( patients in this study, which encourage further work to assess whether the reference vitamin D level currently used in the general population is applicable to HD patients.